Nonparametric multiple test procedures for dose finding

Show Li Jan; Gwowen Shieh

doi:10.1081/SAC-200040305

Nonparametric multiple test procedures for dose finding

Show Li Jan^*, Gwowen Shieh

^*Corresponding author for this work

Department of Management Science

Research output: Contribution to journal › Article › peer-review

1 Scopus citations

Abstract

We consider identifying the minimum effective dose (MED) in a one-way layout, where the MED is denned to be the lowest dose level that is more effective than the zero-dose control. Proposed herein are two rank-based nonparametric step-down closed testing procedures that do not make order assumptions on the dose-response relationship. The corresponding p-value for the estimated MED is computed. A numerical example is given to illustrate the proposed tests. Finally, the results of a Monte Carlo study of the relative error rate and power performances are reported.

Original language	English
Pages (from-to)	1021-1037
Number of pages	17
Journal	Communications in Statistics Part B: Simulation and Computation
Volume	33
Issue number	4
DOIs	https://doi.org/10.1081/SAC-200040305
State	Published - 1 Jan 2004

Keywords

Dose-response study
Minimum effective dose
One-way layout
Step-down closed test

Access to Document

10.1081/SAC-200040305

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