We consider identifying the minimum effective dose (MED) in a one-way layout, where the MED is denned to be the lowest dose level that is more effective than the zero-dose control. Proposed herein are two rank-based nonparametric step-down closed testing procedures that do not make order assumptions on the dose-response relationship. The corresponding p-value for the estimated MED is computed. A numerical example is given to illustrate the proposed tests. Finally, the results of a Monte Carlo study of the relative error rate and power performances are reported.
|Number of pages||17|
|Journal||Communications in Statistics Part B: Simulation and Computation|
|State||Published - 1 Jan 2004|
- Dose-response study
- Minimum effective dose
- One-way layout
- Step-down closed test