Nonparametric multiple test procedures for dose finding

Show Li Jan*, Gwowen Shieh

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

1 Scopus citations

Abstract

We consider identifying the minimum effective dose (MED) in a one-way layout, where the MED is denned to be the lowest dose level that is more effective than the zero-dose control. Proposed herein are two rank-based nonparametric step-down closed testing procedures that do not make order assumptions on the dose-response relationship. The corresponding p-value for the estimated MED is computed. A numerical example is given to illustrate the proposed tests. Finally, the results of a Monte Carlo study of the relative error rate and power performances are reported.

Original languageEnglish
Pages (from-to)1021-1037
Number of pages17
JournalCommunications in Statistics Part B: Simulation and Computation
Volume33
Issue number4
DOIs
StatePublished - 1 Jan 2004

Keywords

  • Dose-response study
  • Minimum effective dose
  • One-way layout
  • Step-down closed test

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