Nondestructive micropatterning of living animal cells using focused femtosecond laser-induced impulsive force

Takahiro Kaji*, Syoji Ito, Hiroshi Miyasaka, Yoichiroh Hosokawa, Hiroshi Masuhara, Chisa Shukunami, Yuji Hiraki

*Corresponding author for this work

Research output: Contribution to journalArticle

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Abstract

Micropatterning of mouse NIH3T3 fibroblast cells was performed using focused femtosecond laser-induced impulsive force in a culture medium. The cells were detached from an upper substrate by the force and transferred to an underlying substrate with less than spatial resolution of 80 μm full width at half maximum. About 80% of the cells were confirmed to be alive at 3 h after the patterning. The force exerted to the cell was investigated by high-speed imaging and estimated to be an order of micronewtons. The force origin was not only due to cavitation bubble but also due to shockwave and jet flow.

Original languageEnglish
Article number023904
JournalApplied Physics Letters
Volume91
Issue number2
DOIs
StatePublished - 1 Aug 2007

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