Non-lethal Candida albicans cph1/cph1 efg1/efg1 mutant partially protects mice from systemic infections by lethal wild-type cells

Yun-Liang Yang; Chih-Wei Wang; Chiung-Tony Chen; Min-Hsien Wang; Chin Fu Hsiao; Hsiu Juny Lo

doi:10.1016/j.mycres.2008.11.016

Non-lethal Candida albicans cph1/cph1 efg1/efg1 mutant partially protects mice from systemic infections by lethal wild-type cells

Yun-Liang Yang, Chih-Wei Wang, Chiung-Tony Chen, Min-Hsien Wang, Chin Fu Hsiao, Hsiu Juny Lo

Department of Biological Science and Technology

Research output: Contribution to journal › Article › peer-review

6 Scopus citations

Abstract

Although Candida albicans cph1/cph1 efg1/efg1 mutant cells are not lethal to mice, they proliferated in infected mice instead of simply being cleared by the host immune system. Here, we have shown that the cph1/cph1 efg1/efg1 mutant partially protects mice from systemic infections by the lethal wild-type Candida albicans cells. Our results further indicate that a second dose of the cph1/cph1 efg1/efg1 mutant did not boost the degree of protection. (c) 2008 The British Mycological Society. Published by Elsevier Ltd. All rights reserved.

Original language	English
Pages (from-to)	388-390
Number of pages	3
Journal	Mycological Research
DOIs	https://doi.org/10.1016/j.mycres.2008.11.016
State	Published - Mar 2009

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title = "Non-lethal Candida albicans cph1/cph1 efg1/efg1 mutant partially protects mice from systemic infections by lethal wild-type cells",

abstract = "Although Candida albicans cph1/cph1 efg1/efg1 mutant cells are not lethal to mice, they proliferated in infected mice instead of simply being cleared by the host immune system. Here, we have shown that the cph1/cph1 efg1/efg1 mutant partially protects mice from systemic infections by the lethal wild-type Candida albicans cells. Our results further indicate that a second dose of the cph1/cph1 efg1/efg1 mutant did not boost the degree of protection. (c) 2008 The British Mycological Society. Published by Elsevier Ltd. All rights reserved.",

author = "Yun-Liang Yang and Chih-Wei Wang and Chiung-Tony Chen and Min-Hsien Wang and Hsiao, {Chin Fu} and Lo, {Hsiu Juny}",

year = "2009",

month = mar,

doi = "10.1016/j.mycres.2008.11.016",

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T1 - Non-lethal Candida albicans cph1/cph1 efg1/efg1 mutant partially protects mice from systemic infections by lethal wild-type cells

AU - Yang, Yun-Liang

AU - Wang, Chih-Wei

AU - Chen, Chiung-Tony

AU - Wang, Min-Hsien

AU - Hsiao, Chin Fu

AU - Lo, Hsiu Juny

PY - 2009/3

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AB - Although Candida albicans cph1/cph1 efg1/efg1 mutant cells are not lethal to mice, they proliferated in infected mice instead of simply being cleared by the host immune system. Here, we have shown that the cph1/cph1 efg1/efg1 mutant partially protects mice from systemic infections by the lethal wild-type Candida albicans cells. Our results further indicate that a second dose of the cph1/cph1 efg1/efg1 mutant did not boost the degree of protection. (c) 2008 The British Mycological Society. Published by Elsevier Ltd. All rights reserved.

U2 - 10.1016/j.mycres.2008.11.016

DO - 10.1016/j.mycres.2008.11.016

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JO - Fungal Biology

JF - Fungal Biology

SN - 1878-6146

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