Non-lethal Candida albicans cph1/cph1 efg1/efg1 mutant partially protects mice from systemic infections by lethal wild-type cells

Yun-Liang Yang, Chih-Wei Wang, Chiung-Tony Chen, Min-Hsien Wang, Chin Fu Hsiao, Hsiu Juny Lo

Research output: Contribution to journalArticlepeer-review

6 Scopus citations

Abstract

Although Candida albicans cph1/cph1 efg1/efg1 mutant cells are not lethal to mice, they proliferated in infected mice instead of simply being cleared by the host immune system. Here, we have shown that the cph1/cph1 efg1/efg1 mutant partially protects mice from systemic infections by the lethal wild-type Candida albicans cells. Our results further indicate that a second dose of the cph1/cph1 efg1/efg1 mutant did not boost the degree of protection. (c) 2008 The British Mycological Society. Published by Elsevier Ltd. All rights reserved.
Original languageEnglish
Pages (from-to)388-390
Number of pages3
JournalMycological Research
DOIs
StatePublished - Mar 2009

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