Nitrogen-Philic Cyclization of Acyl Radicals Enables the Synthesis of Lactams

Takahide Fukuyama, Ilhyong Ryu*

*Corresponding author for this work

Research output: Chapter in Book/Report/Conference proceedingChapterpeer-review

1 Scopus citations


This chapter focuses on the synthesis of lactams that is enabled by the high affinity of acyl radicals for the N–C double bond in compounds such as imines, amines, oxazolines, and azides. Such acyl radicals can be generated as the first intermediates via the radical carbonylation with carbon monoxide.

Original languageEnglish
Title of host publicationProgress in Heterocyclic Chemistry
PublisherElsevier Ltd
Number of pages12
StatePublished - 1 Jan 2018

Publication series

NameProgress in Heterocyclic Chemistry
ISSN (Print)0959-6380


  • acyl radicals
  • amidine
  • amine
  • azide
  • carbon monoxide
  • imine
  • lactams
  • nitrogen-philic cyclization
  • radical carbonylation

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