NIR-triggered synergic photo-chemothermal therapy delivered by reduced graphene oxide/carbon/mesoporous silica nanocookies

Yu Wei Chen, Po Jung Chen, Shang Hsiu Hu, I. Wei Chen, San-Yuan Chen*

*Corresponding author for this work

Research output: Contribution to journalArticle

69 Scopus citations

Abstract

A novel photo-responsive drug carrier that doubles as a photothermal agent with a nanocookie-like structure is constructed by coating amorphous carbon on a mesoporous silica support self-assembled on a sheet of reduced graphene oxide. With a large payload (0.88 mmolg-1) of a hydrophobic anticancer drug, (S)-(+)-camptothecin (CPT), nanocookies simultaneously provide a burst-like drug release and intense heat upon near-infrared exposure. Being biocompatible yet with a high efficiency for cell uptake, nanocookies have successfully eradicated subcutaneous tumors in 14 days following a single 5 min NIR irradiation without distal damage. These results demonstrate that the nanocookie is an excellent new delivery platform for local, on-demand, NIR-responsive, combined chemotherapy/hyperthermia for tumor treatment and other biomedical applications.

Original languageEnglish
Pages (from-to)451-459
Number of pages9
JournalAdvanced Functional Materials
Volume24
Issue number4
DOIs
StatePublished - 29 Jan 2014

Keywords

  • carbon
  • chemotherapy
  • hyperthermia
  • mesoporous silica
  • nanocookies
  • reduced graphene oxide

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