Newly reduced graphene oxide/gold oxide neural-chemical interface on multi-channel neural probes to enhance the electrochemical properties for biosensors

Ta Chung Liu, Chao Yi Chu, You Yin Chen, San-Yuan Chen*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

1 Scopus citations

Abstract

In this study, a facile one-step Cyclic Voltammetry (CV) electrophoresis was proposed for designing a reduced graphene oxide/gold oxide (rGO/AuOx) modified electrode by using chloride ions (Cl-) with the simultaneous occurrence of gold oxidation and GO reduction to induce the intimate attachment of negatively charged rGO sheets on the positively charged Au+/Au3+ clusters by electrostatic interaction. The surface microstructure and the oxygen functional groups of rGO/AuOx can be tuned by controlling the dissolution rate of gold via the deposition scan rate. At a low deposition scan rate, the rGO/AuOx electrode with well-dispersive rGO sheets and large active sites can induce rapid electron transfer to promote H2O2 detection. The amperometric response results displayed a relative fast response of less than 5 s with a low detection limit of 0.63 μM (S/N = 3). Also, the rGO/AuOx neural-chemical interface can be modified at the multi-channels on neural probe and they exhibited excellent sensing performance to H2O2. The results demonstrated that the rGO/AuOx modified electrode integrated with a neural probe using this one-step electrochemical deposition can provide a faster response and higher sensitivity by optimizing and controlling the surface microstructures of rGO/AuOx, which would serve as a platform for medical application such as biosensors for multi-sensing.

Original languageEnglish
Pages (from-to)27614-27622
Number of pages9
JournalRSC Advances
Volume6
Issue number33
DOIs
StatePublished - 1 Jan 2016

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