New and efficient routes to norstatine and its analogs with high enantiomeric purity by β-Lactam Synthon Method

Iwao Ojima*, Young Hoon Park, Chung-Ming Sun, Thierry Brigaud, Mangzhu Zhao

*Corresponding author for this work

Research output: Contribution to journalArticle

44 Scopus citations

Abstract

Norstatine and its analogs, i.e., 3-amino-2-hydroxyalkanoic acids, with high enantiomeric purity are obtained through effecient asymmetric synthesis of 3-silyloxy-β-lactams by chiral enolate - imine cyclocondensation, followed by hydrolysis.

Original languageEnglish
Pages (from-to)5737-5740
Number of pages4
JournalTetrahedron Letters
Volume33
Issue number39
DOIs
StatePublished - 22 Sep 1992

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