New and Efficient Coupling Method for the Synthesis of Peptides Bearing the Norstatine Residue and Their Analogs

Iwao Ojima*, Chung-Ming Sun, Young Hoon Park

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

40 Scopus citations

Abstract

Novel ring-opening coupling reactions of enantiomerically pure (3R,4S)-1-(tert-butoxycarbonyl)-3-hydroxy β-lactams 1 with various (S)-amino acid esters 2 including proline methyl ester proceed smoothly at ambient temperature to give the corresponding dipeptides 3 bearing the norstatine residue and its analogs in excellent yields. This new coupling method is applicable to solid-phase peptide syntheses.

Original languageEnglish
Pages (from-to)1249-1250
Number of pages2
JournalJournal of Organic Chemistry
Volume59
Issue number6
DOIs
StatePublished - 1 Mar 1994

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