Neural guidance by open-top SU-8 microfluidic channel

Yi Chung Lo*, Chia Sheng Huang, Wen-Syang Hsu, Chaoen Wang

*Corresponding author for this work

Research output: Chapter in Book/Report/Conference proceedingConference contributionpeer-review

8 Scopus citations

Abstract

Manipulating neuron outgrowth and regeneration is important and attractive in the research fields of biomedical, neurological and tissue engineering. In this paper, we propose a new scheme, i.e. open-top SU-8 microfluidic channel, to generate micropatterns of extracellular matrix (ECM) proteins to guide and control the neuron outgrowth in preferred directions and at designed positions by confinement in a microfluidic system. The open-top SU-8 microfluidic channel, which requires only a small volume (∼0.5μl) of laminin solution to fill the two tanks and microchannel, is 20μm thick and 10μm wide. The culturing of retinal ganglion cells (RGCs) was performed using injured goldfish. The experimental results verify that the open-top SU-8 microfluidic channel is not only workable but also effective for neural guidance.

Original languageEnglish
Title of host publicationProceedings - 2004 International Conference on MEMS, NANO and Smart Systems, ICMENS 2004
EditorsW. Badawy, W. Moussa
Pages671-674
Number of pages4
DOIs
StatePublished - 1 Dec 2004
EventProceedings - 2004 International Conference on MEMS, NANO and Smart Systems, ICMENS 2004 - Banff, Alta., Canada
Duration: 25 Aug 200427 Aug 2004

Publication series

NameProceedings - 2004 International Conference on MEMS, NANO and Smart Systems, ICMENS 2004

Conference

ConferenceProceedings - 2004 International Conference on MEMS, NANO and Smart Systems, ICMENS 2004
CountryCanada
CityBanff, Alta.
Period25/08/0427/08/04

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