Neural control of ventricular rate in ambulatory dogs with pacing-induced sustained atrial fibrillation

Hyung Wook Park, Mark J. Shen, Seongwook Han, Tetsuji Shinohara, Mitsunori Maruyama, Young Soo Lee, Changyu Shen, Chun Hwang, Lan S. Chen, Michael C. Fishbein, Shien-Fong Lin, Peng Sheng Chen*

*Corresponding author for this work

Research output: Contribution to journalArticle

11 Scopus citations

Abstract

Background-We hypothesize that inferior vena cava-inferior atrial ganglionated plexus nerve activity (IVC-IAGPNA) is responsible for ventricular rate (VR) control during atrial fibrillation (AF) in ambulatory dogs. Methods and Results-We recorded bilateral cervical vagal nerve activity (VNA) and IVC-IAGPNA during baseline sinus rhythm and during pacing-induced sustained AF in 6 ambulatory dogs. Integrated nerve activities and average VR were measured every 10 seconds over 24 hours. Left VNA was associated with VR reduction during AF in 5 dogs (from 211 bpm [95% CI, 186-233] to 178 bpm [95% CI, 145-210]; P<0.001) and right VNA in 1 dog (from 208 bpm [95% CI, 197-223] to 181 bpm [95% CI, 163-200]; P<0.01). There were good correlations between IVC-IAGPNA and left VNA in the former 5 dogs and between IVC-IAGPNA and right VNA in the last dog. IVC-IAGPNA was associated with VR reduction in all dogs studied. Right VNA was associated with baseline sinus rate reduction from 105 bpm (95% CI, 95-116) to 77 bpm (95% CI, 64-91; P<0.01) in 4 dogs, whereas left VNA was associated with sinus rate reduction from 111 bpm (95% CI, 90-1250) to 81 bpm (95% CI, 67-103; P<0.01) in 2 dogs. Conclusions-IVC-IAGPNA is invariably associated with VR reduction during AF. In comparison, right or left VNA was associated with VR reduction only when it coactivates with the IVC-IAGPNA. The vagal nerve that controls VR during AF may be different from that which controls sinus rhythm.

Original languageEnglish
Pages (from-to)571-580
Number of pages10
JournalCirculation: Arrhythmia and Electrophysiology
Volume5
Issue number3
DOIs
StatePublished - 1 Jun 2012

Keywords

  • Atrial fibrillation
  • Atrioventricular node
  • Autonomic nervous system
  • ECG
  • Ventricular rate

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    Park, H. W., Shen, M. J., Han, S., Shinohara, T., Maruyama, M., Lee, Y. S., Shen, C., Hwang, C., Chen, L. S., Fishbein, M. C., Lin, S-F., & Chen, P. S. (2012). Neural control of ventricular rate in ambulatory dogs with pacing-induced sustained atrial fibrillation. Circulation: Arrhythmia and Electrophysiology, 5(3), 571-580. https://doi.org/10.1161/CIRCEP.111.967737