Near-infrared optical reflectance microspectroscopy examining atrioventricular valvular rhythm of wildtype larval zebrafish as a pre-stage cardiac drug toxicity assay

Hao Chun Hsieh, Wei Ting Chang, Po Sheng Hu*

*Corresponding author for this work

Research output: Contribution to journalArticle

Abstract

Atrioventricular (AV) valve is a cardiac component of zebrafish that regulates the rhythm of blood flow, and may be utilized to assay unknown cardiac drug compounds. This research herein presents the construction of a near-infrared optical reflectance microspectroscopy (NIRORM), examining the rhythm of AV valve of wildtype zebrafish larvae in vivo as a preliminary drug toxicity assay, of which the experimental results indicate that NIRORM is effective in discriminating types of cardiac drugs based upon the stimulating or tranquilizing effects on AV valve, and such effects are highly dependent on the concentration of solution and duration of sample immersion.

Original languageEnglish
Article number164661
JournalOptik
Volume212
DOIs
StatePublished - Jun 2020

Keywords

  • drug toxicity assay
  • larval zebrafish
  • microspectroscopy
  • near-infrared
  • reflectance

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