Near-infrared brain volumetric imaging method: A monte carlo study

Ching-Cheng Chuang*, Pei Ning Wang, Wei Ta Chen, Tsuo Hung Lan, Chung Ming Chen, Yao Sheng Hsieh, Chun Yang Wang, Chia-Wei Sun

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

4 Scopus citations


The symptom of brain volumetric changes may provide significant biomarker to predict progressive dementia. The brain volumetric changes of prefrontal cortex are highly associated with many neurodegenerative diseases. Besides, brain atrophy reveals the expanded interhemispheric fissure and the concomitant increasing cerebrospinal fluid volume. Thus, the quantitative assessment of brain volumetric changes is an important consideration for clinical studies of neurodegenerative diseases. In this study, we first proposed an approach that uses near-infrared brain volumetric imaging to detect brain volumetric changes. The healthy, aged, and typical Alzheimers disease (AD) brains were modeled with different characterization of brain volumetric changes from in vivo MRI data based on time-resolved 3-D Monte Carlo simulation. In the results, the significant difference of prefrontal cortex structure can be observed among healthy, aged, and AD brain with various source-detector separations in sagittal view. Our study shows that the near-infrared brain volumetric imaging can be an indicator of brain atrophy for clinical application of neurodegenerative diseases with patient-oriented measurement.

Original languageEnglish
Article number5976997
Pages (from-to)1122-1129
Number of pages8
JournalIEEE Journal on Selected Topics in Quantum Electronics
Issue number3
StatePublished - 1 Jan 2012


  • Brain atrophy
  • Monte Carlo simulation
  • brain volumetric imaging (BVI)
  • diffuse optical imaging (DOI)
  • near-infrared spectroscopy (NIRS)
  • prefrontal cortex

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