Ndt80p is involved in L-sorbose utilization through regulating SOU1 in Candida albicans

Hsiu Jung Lo, Wen-Li Chu, Ci-Hong Liou, Szu-Hsuan Huang, Kay-Hooi Khoo, Yun-Liang Yang

Research output: Contribution to journalArticle

Abstract

Ndt80p, a known transcriptional factor, regulates various targets involved in stress responses, filamentous growth, and virulence in Candida albicans. Potential targets of Ndt80p have been identified at the transcriptional level. The present study was conducted to identify genes regulated by Ndt80p from the protein level. We found that the levels of Ahp1p, Fma1p, Hsp21p, Rfa2p, Snz1p, Sod1p, Soul p, Trp99p, orf19.251, orf19.1862, and orf19.5620, were affected by the null mutation of NDT80 by two-dimensional polyacrylamide gel-electrophoresis analysis. Among the 11 proteins, all but Sou1p and Rfa2p are suggested to be involved in known functions of Ndt80p. Here, we demonstrate that Ndt80p plays a role in t-sorbose utilization through regulating SOU1 in C. albicans. (C) 2014 Elsevier GmbH. All rights reserved.
Original languageEnglish
Pages (from-to)170-173
Number of pages4
JournalInternational Journal of Medical microbiology
Volume305
Issue number1
DOIs
StatePublished - Jan 2015

Keywords

  • Yeast; 2D-PAGE analysis; NDT80; Candida
  • AZOLE RESISTANCE; AMPHOTERICIN-B; YEAST; SUSCEPTIBILITIES; FLUCONAZOLE; METABOLISM; PROTEOMICS

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