Nano-hybrid carboxymethyl-hexanoyl chitosan modified with (3-aminopropyl)triethoxysilane for camptothecin delivery

Meng Hsuan Hsiao, Tsan Hua Tung, Chi Sheng Hsiao, Dean-Mo LIu*

*Corresponding author for this work

Research output: Contribution to journalArticle

17 Scopus citations

Abstract

Silane-modified amphiphilic chitosan was synthesized by anchoring a silane coupling agent, (3-aminopropyl)triethoxysilane, to a novel amphiphilic carboxymethyl-hexanoyl chitosan (CHC). The chemical structure of this new organic-inorganic hybrid molecule was characterized by FTIR and 13C-, 29Si-nuclear magnetic resonance, while the structural evolution was examined using scanning electron microscopy (SEM), transmission electron microscopy (TEM), X-ray diffraction (XRD), and dynamic light scattering (DLS). Experimental results indicated a self-assembly behaviour of molecules into nanoparticles with a stable polygonal geometry, consisting of ordered silane layers of 6 nm in thickness. The self-assembly property was found to be influenced by chemical composition and concentration of silane incorporated, while the size can be varied by the amount of anchored silane. It was also demonstrated that such vesicle exhibited excellent cytocompatibility and cellular internalization capability in ARPE-19 cell line, and presented well-controlled encapsulation and release profiles for (S)-(+)-camptothecin. These unique properties render it as a potential drug delivery nanosystem.

Original languageEnglish
Pages (from-to)632-639
Number of pages8
JournalCarbohydrate Polymers
Volume89
Issue number2
DOIs
StatePublished - 20 Jun 2012

Keywords

  • Amphiphiles
  • Chitosan
  • Drug delivery systems
  • Self-assembly
  • Silane

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