Nano-ferrosponges for controlled drug release

Shang Hsiu Hu, Ting Yu Liu, Dean-Mo LIu*, San-Yuan Chen

*Corresponding author for this work

Research output: Contribution to journalArticle

96 Scopus citations

Abstract

Magnetic sponge-like hydrogels (ferrosponges) were fabricated by using an in-situ synthesis of magnetic nanoparticles (MNPs) in the presence of various concentrations of gelatin. The resulting ferrosponges show an interconnected nanopore structure which serves as a reservoir to accommodate therapeutic drugs and the nanoporous networks demonstrate magnetic sensitive behavior under the application of magnetic field. The ferrosponges showed high swelling ratios, together with excellent elasticity and hydrophilicity, allow them to response rapidly to an external magnetic stimulation for fast and repeatable swelling-deswelling (or expansion-contractile) operations. The ferrosponges with lower gelatin concentration exhibited good performance on magnetification. Furthermore, drug release from the ferrosponges is relatively magnetic-sensitive and is dominated by its magnetism and associated interaction between the magnetic nanoparticle and the gelatin matrix under an external magnetic field. Higher MNPs concentration in the ferrosponges exhibited higher degree of magnetic sensitive which is due to stronger interparticle forces. By taking these peculiar magnetic sensitive behaviors of the ferrosponges, a novel drug delivery system can be designed for medical uses.

Original languageEnglish
Pages (from-to)181-189
Number of pages9
JournalJournal of Controlled Release
Volume121
Issue number3
DOIs
StatePublished - 28 Aug 2007

Keywords

  • Controlled drug release
  • Magnetic
  • Nanoparticles
  • Smart
  • Sponge

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