N-acyl-3-hydroxy-β-lactams as key intermediates for taxotere and its analogs

Iwao Ojima*, Martine Zucco, Olivier Duclos, Scott D. Kuduk, Chung-Ming Sun, Young Hoon Park

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

40 Scopus citations

Abstract

(3R,4S)-3-(protected hydroxy)-4-substituted β-lactams bearing N-alkoxycarbonyl, N-arloxycarbonyl, and N-carbamoyl groups are found to be useful for the synthesis of taxotère and its analogs through coupling with baccatin III.

Original languageEnglish
Pages (from-to)2479-2482
Number of pages4
JournalBioorganic and Medicinal Chemistry Letters
Volume3
Issue number11
DOIs
StatePublished - 1 Jan 1993

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