N-acyl-3-hydroxy-β-lactams as key intermediates for taxotere and its analogs

Iwao Ojima; Martine Zucco; Olivier Duclos; Scott D. Kuduk; Chung-Ming Sun; Young Hoon Park

doi:10.1016/S0960-894X(01)80982-3

N-acyl-3-hydroxy-β-lactams as key intermediates for taxotere and its analogs

Iwao Ojima^*, Martine Zucco, Olivier Duclos, Scott D. Kuduk, Chung-Ming Sun, Young Hoon Park

^*Corresponding author for this work

Department of Applied Chemistry

Research output: Contribution to journal › Article › peer-review

40 Scopus citations

Abstract

(3R,4S)-3-(protected hydroxy)-4-substituted β-lactams bearing N-alkoxycarbonyl, N-arloxycarbonyl, and N-carbamoyl groups are found to be useful for the synthesis of taxotère and its analogs through coupling with baccatin III.

Original language	English
Pages (from-to)	2479-2482
Number of pages	4
Journal	Bioorganic and Medicinal Chemistry Letters
Volume	3
Issue number	11
DOIs	https://doi.org/10.1016/S0960-894X(01)80982-3
State	Published - 1 Jan 1993

Access to Document

10.1016/S0960-894X(01)80982-3

Fingerprint Dive into the research topics of 'N-acyl-3-hydroxy-β-lactams as key intermediates for taxotere and its analogs'. Together they form a unique fingerprint.

Cite this

@article{9784c243278f440a8d18735adaacb86e,

title = "N-acyl-3-hydroxy-β-lactams as key intermediates for taxotere and its analogs",

abstract = "(3R,4S)-3-(protected hydroxy)-4-substituted β-lactams bearing N-alkoxycarbonyl, N-arloxycarbonyl, and N-carbamoyl groups are found to be useful for the synthesis of taxot{\`e}re and its analogs through coupling with baccatin III.",

author = "Iwao Ojima and Martine Zucco and Olivier Duclos and Kuduk, {Scott D.} and Chung-Ming Sun and Park, {Young Hoon}",

year = "1993",

month = jan,

day = "1",

doi = "10.1016/S0960-894X(01)80982-3",

language = "English",

volume = "3",

pages = "2479--2482",

journal = "Bioorganic and Medicinal Chemistry Letters",

issn = "0960-894X",

publisher = "Elsevier Limited",

number = "11",

}

TY - JOUR

T1 - N-acyl-3-hydroxy-β-lactams as key intermediates for taxotere and its analogs

AU - Ojima, Iwao

AU - Zucco, Martine

AU - Duclos, Olivier

AU - Kuduk, Scott D.

AU - Sun, Chung-Ming

AU - Park, Young Hoon

PY - 1993/1/1

Y1 - 1993/1/1

N2 - (3R,4S)-3-(protected hydroxy)-4-substituted β-lactams bearing N-alkoxycarbonyl, N-arloxycarbonyl, and N-carbamoyl groups are found to be useful for the synthesis of taxotère and its analogs through coupling with baccatin III.

AB - (3R,4S)-3-(protected hydroxy)-4-substituted β-lactams bearing N-alkoxycarbonyl, N-arloxycarbonyl, and N-carbamoyl groups are found to be useful for the synthesis of taxotère and its analogs through coupling with baccatin III.

UR - http://www.scopus.com/inward/record.url?scp=0027742280&partnerID=8YFLogxK

U2 - 10.1016/S0960-894X(01)80982-3

DO - 10.1016/S0960-894X(01)80982-3

M3 - Article

AN - SCOPUS:0027742280

VL - 3

SP - 2479

EP - 2482

JO - Bioorganic and Medicinal Chemistry Letters

JF - Bioorganic and Medicinal Chemistry Letters

SN - 0960-894X

IS - 11

ER -

N-acyl-3-hydroxy-β-lactams as key intermediates for taxotere and its analogs

Abstract

Access to Document

Other files and links

Cite this