Multitheragnostic Multi-GNRs Crystal-Seeded Magnetic Nanoseaurchin for Enhanced in Vivo Mesenchymal-Stem-Cell Homing, Multimodal Imaging, and Stroke Therapy

Po Jung Chen, Yi Da Kang, Chen Huan Lin, San-Yuan Chen*, Chia Hung Hsieh, You Yin Chen, Chun Wei Chiang, Wei Lee, Chung Y. Hsu, Lun De Liao, Chih Tai Fan, Meng Lin Li, Woei Cherng Shyu

*Corresponding author for this work

Research output: Contribution to journalArticle

31 Scopus citations

Abstract

A multifunctional nanoseaurchin probe in which mesoporous silica nanobeads with iron oxide nanoparticles embedded and multi-gold nanorods crystal-seeded are fabricated and labeled with umbilical cord mesenchymal stem cells through endocytosis. This nanoplatform enables efficient magnetic remote-controlled guiding for stem cell homing, and provides dual modalities of photoacoustic imaging and magnetic resonance imaging for in situ tracking and long-term monitoring to achieve therapeutic efficacy.

Original languageEnglish
Pages (from-to)6488-6495
Number of pages8
JournalAdvanced Materials
Volume27
Issue number41
DOIs
StatePublished - 1 Nov 2015

Keywords

  • magnetic resonance imaging
  • mesenchymal stem cells
  • multitheragnostic multi-GNRs crystal-seeded magnetic nanoseaurchin
  • photoacoustic imaging
  • stroke therapy

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    Chen, P. J., Kang, Y. D., Lin, C. H., Chen, S-Y., Hsieh, C. H., Chen, Y. Y., Chiang, C. W., Lee, W., Hsu, C. Y., Liao, L. D., Fan, C. T., Li, M. L., & Shyu, W. C. (2015). Multitheragnostic Multi-GNRs Crystal-Seeded Magnetic Nanoseaurchin for Enhanced in Vivo Mesenchymal-Stem-Cell Homing, Multimodal Imaging, and Stroke Therapy. Advanced Materials, 27(41), 6488-6495. https://doi.org/10.1002/adma.201502784