Multistep microwave-assisted divergent synthesis of indolo-fused pyrazino-/diazepinoquinoxalinones on PEG support

Jin Ji Lai, Deepak B. Salunke, Chung-Ming Sun*

*Corresponding author for this work

Research output: Contribution to journalArticle

39 Scopus citations

Abstract

Synthesis of amino acid and indoline-substituted dinitrobenzene on a soluble polymer support (PEG) and its further reductive double-ring closure to afford structurally diverse indolo-fused pyrazino-/diazepinoquinoxalinones is described. Traceless synthesis of quinoxalinones coupled with application of the Pictet-Spengler-type condensation reaction furnished these novel scaffolds. These hitherto novel heterocycles are synthesized in shorter times under microwave irradiation conditions in comparison with that of classical reaction conditions.

Original languageEnglish
Pages (from-to)2174-2177
Number of pages4
JournalOrganic Letters
Volume12
Issue number10
DOIs
StatePublished - 21 May 2010

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