Multiscale peak identification for bacterial SERS spectra

Tsung Heng Tsai*, Da Wei Wang, Ting Ting Liu, You Hsuan Lin, Yung Ching Huang, Tian Jiun Liu, Yu Chen, Chi Hung Lin, Juen Kai Wang, Yuh Lin Wang

*Corresponding author for this work

Research output: Chapter in Book/Report/Conference proceedingConference contribution

2 Scopus citations

Abstract

A multiscale approach for peak identification and representation is proposed in the context of surface-enhanced Raman spectroscopy (SERS). The issue of overlapping effects, which frequently appear in biological signals but have not been addressed well in established approaches, is the main concern in this paper. The peak identification will be an ambiguous problem if the overlapping effects are not addressed well. We propose a refinement on our multiscale peak identification (MSP) approach to apply matching pursuit for overlapping effects. The spectral peaks are modeled by the pattern matching method on their preferred scales estimated with the evolution of wavelet transform modulus maxima (WTMM). With the MSP approach, we are able to reconstruct a given SERS spectrum into a set of underlying Gaussian peaks. In the demonstrated experiment regarding the life cycle of Escherichia coli, more meaningful but not steadily accessible features can be derived. Moreover, the explicit peak representation can make the association of SERS spectrum with specific molecular information possible.

Original languageEnglish
Title of host publication3rd International Conference on Bioinformatics and Biomedical Engineering, iCBBE 2009
DOIs
StatePublished - 2009
Event3rd International Conference on Bioinformatics and Biomedical Engineering, iCBBE 2009 - Beijing, China
Duration: 11 Jun 200913 Jun 2009

Publication series

Name3rd International Conference on Bioinformatics and Biomedical Engineering, iCBBE 2009

Conference

Conference3rd International Conference on Bioinformatics and Biomedical Engineering, iCBBE 2009
CountryChina
CityBeijing
Period11/06/0913/06/09

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    Tsai, T. H., Wang, D. W., Liu, T. T., Lin, Y. H., Huang, Y. C., Liu, T. J., Chen, Y., Lin, C. H., Wang, J. K., & Wang, Y. L. (2009). Multiscale peak identification for bacterial SERS spectra. In 3rd International Conference on Bioinformatics and Biomedical Engineering, iCBBE 2009 [5163095] (3rd International Conference on Bioinformatics and Biomedical Engineering, iCBBE 2009). https://doi.org/10.1109/ICBBE.2009.5163095