Multiphoton and confocal imaging of precisely cut oral cancer tumor sections for personalized medicine

Shu Jen Chiang*, Po Hang Tseng, Hsu Cheng Huang, Shih Chi Chen, Shean-Jen Chen, Mei Chun Lin, Pei Jen Lou, Chen Yuan Dong

*Corresponding author for this work

Research output: Chapter in Book/Report/Conference proceedingConference contributionpeer-review

Abstract

Traditionally, testing of therapeutic agents uses two-dimensional cell cultures which does not recapitulate the complex, three-dimensional architecture of tissues. In the case of cancer drug development, immunotherapy (IT) emerged as an effective treatment strategy for the patients who respond to therapy. However, the overall patient response rate for immunotherapy is around 25%. Therefore, there is a need to develop more effective drug testing platform for cancer patients. In this work, we develop three-dimensional tissue cultures of human oral cancer slices. We observed the growth dynamics of the tissue sections for up to 28 days. Their viability over extended periods suggest that the tissue sections may be used for personalized drug testing.

Original languageEnglish
Title of host publicationMultiphoton Microscopy in the Biomedical Sciences XX
EditorsAmmasi Periasamy, Peter T. C. So, Karsten Konig, Karsten Konig
PublisherSPIE
Number of pages5
ISBN (Electronic)9781510632516
DOIs
StatePublished - 21 Feb 2020
EventMultiphoton Microscopy in the Biomedical Sciences XX 2020 - San Francisco, United States
Duration: 2 Feb 20204 Feb 2020

Publication series

NameProgress in Biomedical Optics and Imaging - Proceedings of SPIE
Volume11244
ISSN (Print)1605-7422

Conference

ConferenceMultiphoton Microscopy in the Biomedical Sciences XX 2020
CountryUnited States
CitySan Francisco
Period2/02/204/02/20

Keywords

  • Multiphoton Imaging
  • Oral Cancer
  • Precision Medicine
  • Tumor Sections

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