Multifunctional nanocarriers for simultaneous encapsulation of hydrophobic and hydrophilic drugs in cancer treatment

Chia Wei Su, Chih Sheng Chiang, Wei Ming Li, Shang Hsiu Hu, San-Yuan Chen*

*Corresponding author for this work

Research output: Contribution to journalReview articlepeer-review

27 Scopus citations

Abstract

Combination therapy for cancer patients is an important standard of care protocol because it can elicit synergistic therapeutic effects and reduce systemic toxicity by simultaneously modulating multiple cell-signaling pathways and overcoming multidrug resistance. Nanocarriers are expected to play a major role in delivering multiple drugs to tumor tissues by overcoming biological barriers. However, especially considering the different physical chemistry of chemotherapeutic drugs, it is highly desirable to develop a codelivery nanocarrier for controlled and targeted delivery of both hydrophobic and hydrophilic drugs. This review reports the recent developments in various combinational drug delivery systems and the simultaneous use of combinational drug delivery systems with functional agents.

Original languageEnglish
Pages (from-to)1499-1515
Number of pages17
JournalNanomedicine
Volume9
Issue number10
DOIs
StatePublished - 1 Jul 2014

Keywords

  • combination therapy
  • controlled drug release
  • imaging
  • nanocarrier
  • stimuli-sensitive
  • targeting

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