Multicomponent Synthesis of Functionalized Tetrahydroacridinones: Insights into a Mechanistic Route

Tsai Wen Chung, Bharat D. Narhe, Chun Cheng Lin, Chung-Ming Sun*

*Corresponding author for this work

Research output: Contribution to journalArticle

14 Scopus citations

Abstract

A mechanistic study of three-component reactions of various aromatic amines with a number of aldehydes and 1,3-diones was achieved. The unprecedented reaction involved a nucleophilic attack of an aromatic amine on the in situ generated Michael adduct intermediate followed by six-electron ring cyclizations. It is contrary to the common belief that advocates involvement of coupling reactions between a Knoevenagel adduct and an aromatic amine to deliver substituted tetrahydroacridinones.

Original languageEnglish
Pages (from-to)5368-5371
Number of pages4
JournalOrganic Letters
Volume17
Issue number21
DOIs
StatePublished - 6 Nov 2015

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