Multi-level droplet routing in active-matrix based digital-microfluidic biochips

Guan Ruei Lu, Bhargab B. Bhattacharya, Tsung Yi Ho, Hung-Ming Chen

Research output: Chapter in Book/Report/Conference proceedingConference contribution

6 Scopus citations

Abstract

Active-Matrix (AM) technology is currently being used to implement a superior class of EWOD-based biochips, which consist of a dense 2D-array of microelectrodes. These chips offer many advantages over conventional biochips such as the capability of handling variable-size droplets, more flexibility in droplet movement, precise control over droplet navigation, and as a sequel, ease of implementing complex bioprotocols on-chip. However, the new technology poses a number of challenges concerning droplet routing. In order to enhance routability, we propose, in this paper, a multi-level hierarchical approach that takes appropriate decisions on droplet splitting and reshaping. Compared to the most recent routing methods used for EWOD, the proposed multi-level router reduces maximum latest-arrivaltime by an average 18% and achieves 7% less average latest-arrival-time.

Original languageEnglish
Title of host publicationASP-DAC 2018 - 23rd Asia and South Pacific Design Automation Conference, Proceedings
PublisherInstitute of Electrical and Electronics Engineers Inc.
Pages46-51
Number of pages6
ISBN (Electronic)9781509006021
DOIs
StatePublished - 20 Feb 2018
Event23rd Asia and South Pacific Design Automation Conference, ASP-DAC 2018 - Jeju, Korea, Republic of
Duration: 22 Jan 201825 Jan 2018

Publication series

NameProceedings of the Asia and South Pacific Design Automation Conference, ASP-DAC
Volume2018-January

Conference

Conference23rd Asia and South Pacific Design Automation Conference, ASP-DAC 2018
CountryKorea, Republic of
CityJeju
Period22/01/1825/01/18

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    Lu, G. R., Bhattacharya, B. B., Ho, T. Y., & Chen, H-M. (2018). Multi-level droplet routing in active-matrix based digital-microfluidic biochips. In ASP-DAC 2018 - 23rd Asia and South Pacific Design Automation Conference, Proceedings (pp. 46-51). (Proceedings of the Asia and South Pacific Design Automation Conference, ASP-DAC; Vol. 2018-January). Institute of Electrical and Electronics Engineers Inc.. https://doi.org/10.1109/ASPDAC.2018.8297281