Molecular design of near-infrared fluorescent Pdots for tumor targeting: Aggregation-induced emission: Versus anti-aggregation-caused quenching

Wei Kai Tsai, Chun I. Wang, Chia Hsien Liao, Chun Nien Yao, Tsai Jhen Kuo, Ming Ho Liu, Chao Ping Hsu, Shu Yi Lin, Chang Yi Wu, Joseph R. Pyle, Jixin Chen, Yang-Hsiang Chan*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

8 Scopus citations

Abstract

Semiconducting polymer dots (Pdots) have recently emerged as a new type of ultrabright fluorescent probe that has been proved to be very useful for biomedical imaging. However, Pdots often suffer from serious fluorescence aggregation-caused quenching (ACQ) especially for near-infrared (NIR) fluorescent Pdots. This article compared two strategies to overcome the ACQ effect in near-infrared emissive Pdot systems: aggregation-induced emission (AIE) and anti-aggregation-caused quenching (anti-ACQ). The results show that the anti-ACQ platform outperforms the AIE system. The fluorescence quantum yield of anti-ACQ-based Pdots can be over 50% and the average per-particle brightness of the Pdots is about 5 times higher than that of the commercially available quantum dots. To help understand why the monomer conformations could greatly affect the optical properties of Pdots, molecular dynamics simulations were performed for the first time in such complicated Pdot systems. To demonstrate applications for in vivo fluorescence imaging, both microangiography imaging on living zebrafish embryos and specific tumor targeting on mice were performed. We anticipate that these studies will pave the way for the design of new highly fluorescent Pdot systems.

Original languageEnglish
Pages (from-to)198-207
Number of pages10
JournalChemical Science
Volume10
Issue number1
DOIs
StatePublished - 1 Jan 2019

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