Modernized low pressure carbonylation methods in batch and flow employing common acids as a CO source

Célia Brancour, Takahide Fukuyama*, Yu Mukai, Troels Skrydstrup, Ilhyong Ryu

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

131 Scopus citations

Abstract

Carbonylation reactions, such as Heck, Sonogashira, and radical carbonylations, were successfully carried out in a "two-chamber reactor" where carbon monoxide was produced ex situ by the Morgan reaction (dehydration of formic acid by sulfuric acid). By a subsequent application in a microflow system using a "tube-in-tube" reactor where gas-permeable Teflon AF2400 was used as the inner tube, it is demonstrated that formic acid/sulfuric acid can be employed concomitantly with an amine base such as triethylamine in the Heck aminocarbonylation of aryl iodide.

Original languageEnglish
Pages (from-to)2794-2797
Number of pages4
JournalOrganic Letters
Volume15
Issue number11
DOIs
StatePublished - 26 Jun 2013

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