Modeling and measurement of elastic laminae in arteries

Hai Xu, Jin-Jia Hu, Jay D. Humphrey, Jyh Charn Liu*

*Corresponding author for this work

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Abstract

Analysis of elastic laminae provides vital information on both the gross and fine structures of the arterial wall, which is vital to assess issues such as mechanical damage caused by cardiovascular disease or clinical treatment. For example, the distribution of thickness, and distance between them, of the elastic laminae within the aorta can provide important clues on how hypertension affects aortic structure temporally. The requisite microscopic (i.e., histologic or immunohistologic) images have numerous segments, making their measurement and characterization a laborious and inaccurate task. In this paper, we propose a novel scheme for automated analysis of lamina thickness. Results show that our scheme can accurately orient image samples, and detect and calculate thickness distribution in cross sections of the aorta. This new technique not only drastically reduces the human labor, it also eliminates inevitable errors and inconsistencies of manual measurements. 1

Original languageEnglish
Title of host publication2006 3rd IEEE International Symposium on Biomedical Imaging
Subtitle of host publicationFrom Nano to Macro - Proceedings
Pages626-629
Number of pages4
DOIs
StatePublished - 17 Nov 2006
Event2006 3rd IEEE International Symposium on Biomedical Imaging: From Nano to Macro - Arlington, VA, United States
Duration: 6 Apr 20069 Apr 2006

Publication series

Name2006 3rd IEEE International Symposium on Biomedical Imaging: From Nano to Macro - Proceedings
Volume2006

Conference

Conference2006 3rd IEEE International Symposium on Biomedical Imaging: From Nano to Macro
CountryUnited States
CityArlington, VA
Period6/04/069/04/06

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    Xu, H., Hu, J-J., Humphrey, J. D., & Liu, J. C. (2006). Modeling and measurement of elastic laminae in arteries. In 2006 3rd IEEE International Symposium on Biomedical Imaging: From Nano to Macro - Proceedings (pp. 626-629). [1624994] (2006 3rd IEEE International Symposium on Biomedical Imaging: From Nano to Macro - Proceedings; Vol. 2006). https://doi.org/10.1109/ISBI.2006.1624994