MiRTarBase update 2018: A resource for experimentally validated microRNA-target interactions

Chih Hung Chou, Sirjana Shrestha, Chi Dung Yang, Nai Wen Chang, Yu Ling Lin, Kuang-Wen Liao, Wei Chi Huang, Ting Hsuan Sun, Siang Jyun Tu, Wei Hsiang Lee, Men Yee Chiew, Chun San Tai, Ting Yen Wei, Tzi Ren Tsai, Hsin Tzu Huang, Chung Yu Wang, Hsin Yi Wu, Shu Yi Ho, Pin Rong Chen, Cheng Hsun ChuangPei Jung Hsieh, Yi Shin Wu, Wen-Liang Chen, Meng Ju Li, Yu Chun Wu, Xin Yi Huang, Fung Ling Ng, Waradee Buddhakosai, Pei Chun Huang, Kuan Chun Lan, Chia Yen Huang, Shun Long Weng, Yeong Nan Cheng, Chao Liang, Wen Lian Hsu, Hsien Da Huang*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

805 Scopus citations

Abstract

MicroRNAs (miRNAs) are small non-coding RNAs of â 1/4 22 nucleotides that are involved in negative regulation of mRNA at the post-transcriptional level. Previously, we developed miRTarBase which provides information about experimentally validated miRNA-target interactions (MTIs). Here, we describe an updated database containing 422 517 curated MTIs from 4076 miRNAs and 23 054 target genes collected from over 8500 articles. The number of MTIs curated by strong evidence has increased â 1/41.4-fold since the last update in 2016. In this updated version, target sites validated by reporter assay that are available in the literature can be downloaded. The target site sequence can extract new features for analysis via a machine learning approach which can help to evaluate the performance of miRNA-target prediction tools. Furthermore, different ways of browsing enhance user browsing specific MTIs. With these improvements, miRTarBase serves as more comprehensively annotated, experimentally validated miRNA-target interactions databases in the field of miRNA related research. miRTarBase is available at http://miRTarBase.mbc.nctu.edu.tw/.

Original languageEnglish
Pages (from-to)D296-D302
JournalNucleic acids research
Volume46
Issue numberD1
DOIs
StatePublished - 1 Jan 2018

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