Microwave-assisted soluble polymer-supported synthesis of benzopiperazinones

Wong Jin Chang, Wen Ben Yeh, Chung-Ming Sun*

*Corresponding author for this work

Research output: Contribution to journalArticle

35 Scopus citations

Abstract

Microwave-assisted liquid-phase combinatorial synthesis of quinoxaline-2-ones is reported. Immobilized aryl fluoride was aminated via ipso-fluoro displacement and then reduced the adjacent nitro group to give polymer bound o-phenylenediamine in the microwave oven. Spontaneous condensation and intramolecular cyclization of diamines with chloroacetyl chloride under microwave irradiation resulted in the formation of quinoxaline-2-ones as a combinatorial scaffold. Analytically pure target molecules were isolated after cleavage of the polymer support. All reactions involved were performed completely within a few minutes under microwave exposure.

Original languageEnglish
Pages (from-to)1688-1692
Number of pages5
JournalSynlett
Issue number11
DOIs
StatePublished - 1 Jan 2003

Keywords

  • Combinatorial synthesis
  • Microwave-assisted
  • Quinoxaline-2-ones

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