Microwave-assisted efficient conjugation of nanodiamond and paclitaxel

Yi Han Hsieh, Kuang Kai Liu, Rohidas S. Sulake, Jui-I Chao*, Chinpiao Chen

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

8 Scopus citations

Abstract

Nanodiamond has recently received considerable attention due to the various possible applications in medical field such as drug delivery and bio-labeling. For this purpose suitable and effective surface functionalization of the diamond material are required. A versatile and reproducible surface modification method of nanoscale diamond is essential for functionalization. We introduce the input of microwave energy to assist the functionalization of nanodiamond surface. The feasibility of such a process is illustrated by comparing the biological assay of ND-paclitaxel synthesized by conventional and microwave irradiating. Using a microwave we manage to have approximately doubled grafted molecules per nanoparticle of nanodiamond.

Original languageEnglish
Pages (from-to)2074-2077
Number of pages4
JournalBioorganic and Medicinal Chemistry Letters
Volume25
Issue number10
DOIs
StatePublished - 15 Jun 2015

Keywords

  • Deaggregation
  • Lung cancer
  • Microwave irradiating
  • Nanodiamond
  • Paclitaxel

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