Microwave-assisted benzimidazole cyclization by bismuth chloride

Yuh Sheng Su, Chung-Ming Sun*

*Corresponding author for this work

Research output: Contribution to journalArticle

21 Scopus citations

Abstract

We have developed a multi-step, microwave-assisted method for the bismuth chloride catalyzed synthesis of 1,2-disubstituted benzimidazoles. Biologically interesting benzimidazoles were readily assembled using a SNAr reaction, reduction, and finally a bismuth(III)-mediated cyclization under microwave irradiation. The desired products were then liberated from the soluble matrix in excellent yield and purity after cleavage. Each step of the synthetic sequence was performed under microwave conditions.

Original languageEnglish
Pages (from-to)1243-1246
Number of pages4
JournalSynlett
Issue number8
DOIs
StatePublished - 17 May 2005

Keywords

  • Bismuth chloride
  • Combinatorial chemistry
  • Liquid-phase method
  • Microwave assisted synthesis
  • Scaffold

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