Microwave-assisted benzimidazole cyclization by bismuth chloride

Yuh Sheng Su, Chung-Ming Sun*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

21 Scopus citations


We have developed a multi-step, microwave-assisted method for the bismuth chloride catalyzed synthesis of 1,2-disubstituted benzimidazoles. Biologically interesting benzimidazoles were readily assembled using a SNAr reaction, reduction, and finally a bismuth(III)-mediated cyclization under microwave irradiation. The desired products were then liberated from the soluble matrix in excellent yield and purity after cleavage. Each step of the synthetic sequence was performed under microwave conditions.

Original languageEnglish
Pages (from-to)1243-1246
Number of pages4
Issue number8
StatePublished - 17 May 2005


  • Bismuth chloride
  • Combinatorial chemistry
  • Liquid-phase method
  • Microwave assisted synthesis
  • Scaffold

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