MicroRNAs, Parkinson’s disease, and diabetes mellitus

Hsiuying Wang*

*Corresponding author for this work

Research output: Contribution to journalReview articlepeer-review

Abstract

Parkinson’s disease (PD) is a neurodegenerative disorder that affects 1% of the population over the age of 60. Diabetes Mellitus (DM) is a metabolic disorder that affects approximately 25% of adults over the age of 60. Recent studies showed that DM increases the risk of developing PD. The link between DM and PD has been discussed in the literature in relation to different mechanisms including mitochondrial dysfunction, oxidative stress, and protein aggregation. In this paper, we review the common microRNA (miRNA) biomarkers of both diseases. miRNAs play an important role in cell differentiation, development, the regulation of the cell cycle, and apoptosis. They are also involved in the pathology of many diseases. miRNAs can mediate the insulin pathway and glucose absorption. miRNAs can also regulate PD-related genes. Therefore, exploring the common miRNA biomarkers of both PD and DM can shed a light on how these two diseases are correlated, and targeting miRNAs is a potential therapeutic opportunity for both diseases.

Original languageEnglish
Article number2953
Pages (from-to)1-18
Number of pages18
JournalInternational Journal Of Molecular Sciences
Volume22
Issue number6
DOIs
StatePublished - 2 Mar 2021

Keywords

  • Biomarker
  • Diabetes mellitus
  • MicroRNA
  • Parkinson’s disease

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