MicroRNAs and Apoptosis in Colorectal Cancer

Hsiuying Wang*

*Corresponding author for this work

Research output: Contribution to journalReview articlepeer-review

2 Scopus citations

Abstract

Colorectal cancer (CRC) is the third leading cause of cancer death in the world, and its incidence is rising in developing countries. Treatment with 5-Fluorouracil (5-FU) is known to improve survival in CRC patients. Most anti-cancer therapies trigger apoptosis induction to eliminate malignant cells. However, de-regulated apoptotic signaling allows cancer cells to escape this signaling, leading to therapeutic resistance. Treatment resistance is a major challenge in the development of effective therapies. The microRNAs (miRNAs) play important roles in CRC treatment resistance and CRC progression and apoptosis. This review discusses the role of miRNAs in contributing to the promotion or inhibition of apoptosis in CRC and the role of miRNAs in modulating treatment resistance in CRC cells.

Original languageEnglish
Article number5353
Number of pages15
JournalInternational journal of molecular sciences
Volume21
Issue number15
DOIs
StatePublished - Aug 2020

Keywords

  • apoptosis
  • colorectal cancer
  • microRNA
  • resistance
  • COLON-CANCER
  • PROMOTES APOPTOSIS
  • TUMOR-SUPPRESSOR
  • DRUG-RESISTANCE
  • DOWN-REGULATION
  • CELL-PROLIFERATION
  • SMALL RNAS
  • EXPRESSION
  • 5-FLUOROURACIL
  • PROGRESSION

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