MicroRNA, Diabetes Mellitus and Colorectal Cancer

Hsiu-Ying Wang*

*Corresponding author for this work

Research output: Contribution to journalReview articlepeer-review

1 Scopus citations

Abstract

Diabetes mellitus (DM) is an endocrinological disorder that is due to either the pancreas not producing enough insulin, or the body does not respond appropriately to insulin. There are many complications of DM such as retinopathy, nephropathy, and peripheral neuropathy. In addition to these complications, DM was reported to be associated with different cancers. In this review, we discuss the association between DM and colorectal cancer (CRC). CRC is the third most commonly diagnosed cancer worldwide that mostly affects older people, however, its incidence and mortality are rising among young people. We discuss the relationship between DM and CRC based on their common microRNA (miRNA) biomarkers. miRNAs are non-coding RNAs playing important functions in cell differentiation, development, regulation of cell cycle, and apoptosis. miRNAs can inhibit cell proliferation and induce apoptosis in CRC cells. miRNAs also can improve glucose tolerance and insulin sensitivity. Therefore, investigating the common miRNA biomarkers of both DM and CRC can shed a light on how these two diseases are correlated and more understanding of the link between these two diseases can help the prevention of both DM and CRC.

Original languageEnglish
Article number530
Number of pages17
JournalBiomedicines
Volume8
Issue number12
DOIs
StatePublished - Dec 2020

Keywords

  • biomarkers
  • colorectal cancer
  • diabetes mellitus
  • glucose
  • insulin
  • microRNA
  • COLON-CANCER
  • DOWN-REGULATION
  • PROMOTES APOPTOSIS
  • TUMOR-SUPPRESSOR
  • CELL-PROLIFERATION
  • PATHOGENIC ROLE
  • EXPRESSION
  • 5-FLUOROURACIL
  • MIRNAS
  • DYSFUNCTION

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