Microfluidic systems using localized molecular imprinting polymers for detection of nano-scale bio-molecules based on surface plasmon resonance

Gwo Bin Lee*, Shean-Jen Chen, Shih Chiang Huang, Fan Ching Chien, Wen Janq Chen

*Corresponding author for this work

Research output: Chapter in Book/Report/Conference proceedingConference contributionpeer-review

2 Scopus citations

Abstract

This paper reports a new microfluidic system integrated with localized molecular imprinting polymers (MIP) for detection of nano-scale bio-molecules based on surface plasmon resonance (SPR). The label-free bio-sensing method incorporates SPR biosensing and an innovative microfluidic biochip capable of transporting a specific amount of bio-samples inside multiple microchannels using micropumps to sensing regions where multiple MIP films are locally spun-coated such that highly-sensitive, high-throughput, and highly-specific bio-sensing of nano-scale bio-molecules could be achieved. The microfluidic SPR/MIP biochips have the potential to be widely used for nano bio-sensing applications. While compared to large-scale SPR techniques, the developed microfluidic system has a comparable sensitivity with less consumption of samples and can perform the sensing in an automatic format.

Original languageEnglish
Title of host publication2005 5th IEEE Conference on Nanotechnology
Pages113-116
Number of pages4
DOIs
StatePublished - 1 Dec 2005
Event2005 5th IEEE Conference on Nanotechnology - Nagoya, Japan
Duration: 11 Jul 200515 Jul 2005

Publication series

Name2005 5th IEEE Conference on Nanotechnology
Volume2

Conference

Conference2005 5th IEEE Conference on Nanotechnology
CountryJapan
CityNagoya
Period11/07/0515/07/05

Keywords

  • Microfluidics
  • Micropumps
  • MIP
  • SPR

Fingerprint Dive into the research topics of 'Microfluidic systems using localized molecular imprinting polymers for detection of nano-scale bio-molecules based on surface plasmon resonance'. Together they form a unique fingerprint.

Cite this