Micro-channel fabrication by femtosecond laser to arrange neuronal cells on multi-electrode arrays

Chie Hosokawa*, Suguru N. Kudoh, Mariko Suzuki, Ai Kiyohara, Yoichiroh Hosokawa, Kazunori Okano, Hiroshi Masuhara, Takahisa Taguchi

*Corresponding author for this work

Research output: Contribution to journalArticle

10 Scopus citations

Abstract

We propose and demonstrate micro-channel fabrication by femtosecond-laser processing to arrange neuronal cells on multi-electrode arrays (MEAs). When neuronal cells were seeded in the micro-channels on MEAs, they elongated their neurites along the channel and finally formed the network patterned on MEAs. The spontaneous electrical activity of the neuronal networks on MEAs was evaluated by using electrophysiological systems, indicating that patterned network was functionally activated along the channels. The present method is applicable to analyze network dynamics of living neuronal cells patterned artificially.

Original languageEnglish
Pages (from-to)423-428
Number of pages6
JournalApplied Physics A: Materials Science and Processing
Volume101
Issue number2
DOIs
StatePublished - 1 Nov 2010

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