Methods for the analysis of the kinetics of cooperative binding of ligands to a two‐site lattice

Mary E. Edgerton*, Frank A. Handler, Cheng-Wen Wu Lee

*Corresponding author for this work

Research output: Contribution to journalArticle

1 Scopus citations

Abstract

Solutions are obtained that describe the time dependence of the reversible binding of a ligand to a two‐site lattice. The binding may be cooperative. Three methods are used to obtain these solutions: the separation of on/off processes with a variable transformation, the asymptotic series analysis, and the singular perturbation procedure. Applications to parameter calculation from experimental data are presented. This kinetic system is such that it is difficult to extract all kinetic parameters from data analysis, and the implications for each method are also discussed.

Original languageEnglish
Pages (from-to)787-805
Number of pages19
JournalBiopolymers
Volume22
Issue number2
DOIs
StatePublished - 1 Jan 1983

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