MethHC: a database of DNA methylation and gene expression in human cancer

Wei Yun Huang, Sheng Da Hsu, Hsi-Yuan Huang, Yi-Ming Sun, Chih-Hung Chou, Shun Long Weng, Hsien-Da Huang

Research output: Contribution to journalArticlepeer-review

196 Scopus citations

Abstract

We present MethHC (http://MethHC.mbc.nctu.edu.tw), a database comprising a systematic integration of a large collection of DNA methylation data and mRNA/microRNA expression profiles in human cancer. DNA methylation is an important epigenetic regulator of gene transcription, and genes with high levels of DNA methylation in their promoter regions are transcriptionally silent. Increasing numbers of DNA methylation and mRNA/microRNA expression profiles are being published in different public repositories. These data can help researchers to identify epigenetic patterns that are important for carcinogenesis. MethHC integrates data such as DNA methylation, mRNA expression, DNA methylation of microRNA gene and microRNA expression to identify correlations between DNA methylation and mRNA/microRNA expression from TCGA (The Cancer Genome Atlas), which includes 18 human cancers in more than 6000 samples, 6548 microarrays and 12 567 RNA sequencing data.
Original languageEnglish
Pages (from-to)D856-D861
Number of pages6
JournalNucleic Acids Research
Volume43
Issue numberD1
DOIs
StatePublished - 28 Jan 2015

Keywords

  • PROSTATE-CANCER; COLORECTAL-CANCER; HUMAN-DISEASE; START SITES; HYPERMETHYLATION; DIAGNOSIS; BIOMARKERS; PROGNOSIS; MARKERS

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