Metabolic engineering for 1-butanol production from glucose or carbon dioxide

Ethan I. Lan*, Claire R. Shen, Yasumasa Dekishima, James C. Liao

*Corresponding author for this work

Research output: Chapter in Book/Report/Conference proceedingConference contributionpeer-review


Production of chemicals or fuels from renewable sources is an attractive approach to solving the energy and environmental problems. 1-Butanol, a chemical feedstock and potential fuel, has been produced by fermentation of carbohydrates, both in native Clostridium species and various engineered hosts. Clostridial or CoA-dependent 1-butanol production pathway utilizes the same chemistry as the fatty acid biosynthesis. Therefore this pathway may be extended further for the production of other even-number longer chain alcohols. We demonstrate that high titer and high yield 1-butanol production from glucose in E. coli is enabled by engineering driving forces. Production of 1-butanol directly from CO 2 using genetically modified cyanobacteria will also be discussed. Together, these results demonstrate the feasibility of producing even-number longer chain alcohols from renewable sources.

Original languageEnglish
Title of host publication11AIChE - 2011 AIChE Annual Meeting, Conference Proceedings
StatePublished - 1 Dec 2011
Event2011 AIChE Annual Meeting, 11AIChE - Minneapolis, MN, United States
Duration: 16 Oct 201121 Oct 2011

Publication series

Name11AIChE - 2011 AIChE Annual Meeting, Conference Proceedings


Conference2011 AIChE Annual Meeting, 11AIChE
CountryUnited States
CityMinneapolis, MN

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