Measurement of both viscous and elastic constants of a red blood cell in a microchannel

Atsushi Kirimoto*, Hiroaki Ito, Chia-Hung Tsai, Makoto Kaneko

*Corresponding author for this work

Research output: Chapter in Book/Report/Conference proceedingConference contribution

4 Scopus citations

Abstract

In this paper, we propose a novel measurement of both viscous and elastic constants of a red blood cell (RBC) in a microfluidic channel. Although simultaneous measurement of absolute values of RBC viscosity and elasticity has been difficult in a microfluidic channel so far, here we achieved it using precise feedback cell manipulation inside the microchannel. According to deformed shape and theoretically estimated shear force, we first obtained Young's modulus, consistent with that obtained in the previous methods with force sensors. In addition, conducting 'Loading examination' for the same RBC in the downstream of the microchannel, we succeeded in the estimation of absolute values of viscous and elastic constants of a RBC.

Original languageEnglish
Title of host publication2018 IEEE Micro Electro Mechanical Systems, MEMS 2018
PublisherInstitute of Electrical and Electronics Engineers Inc.
Pages388-391
Number of pages4
ISBN (Electronic)9781538647820
DOIs
StatePublished - 24 Apr 2018
Event31st IEEE International Conference on Micro Electro Mechanical Systems, MEMS 2018 - Belfast, United Kingdom
Duration: 21 Jan 201825 Jan 2018

Publication series

NameProceedings of the IEEE International Conference on Micro Electro Mechanical Systems (MEMS)
Volume2018-January
ISSN (Print)1084-6999

Conference

Conference31st IEEE International Conference on Micro Electro Mechanical Systems, MEMS 2018
CountryUnited Kingdom
CityBelfast
Period21/01/1825/01/18

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    Kirimoto, A., Ito, H., Tsai, C-H., & Kaneko, M. (2018). Measurement of both viscous and elastic constants of a red blood cell in a microchannel. In 2018 IEEE Micro Electro Mechanical Systems, MEMS 2018 (pp. 388-391). (Proceedings of the IEEE International Conference on Micro Electro Mechanical Systems (MEMS); Vol. 2018-January). Institute of Electrical and Electronics Engineers Inc.. https://doi.org/10.1109/MEMSYS.2018.8346569