Mapping billions of short reads to a reference genome

Jui-Hung Hung, Zhiping Weng

Research output: Contribution to journalArticle

2 Scopus citations

Abstract

Rapid development and commercialization of instruments that can accurately, rapidly, and cheaply sequence billions of DNA bases is revolutionizing molecular biology and medicine. Because a reference genome is usually available, the first bioinformatics challenge presented by the new generation of highthroughput sequencers is the genome mapping problem, where each read is mapped to a reference genome to reveal its location(s). An introduction to mapping algorithms, as well as factors that influence their results, is provided here.

Original languageEnglish
Pages (from-to)14-17
Number of pages4
JournalCold Spring Harbor Protocols
Volume2017
Issue number1
DOIs
StatePublished - 1 Jan 2017

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