Because the bio-signals are often very weak, they can be influenced by noise easily and become hard to distinguish. In this paper, an automatic analog synthesis platform is presented for bio-acquisition systems to generate the required circuits from specification to layout with low-noise consideration. Process variations and layout effects are also simultaneously considered to generate the required circuits with high design yield. Furthermore, a user-friendly GUI is also provided to help users complete the design flow successfully and efficiently. As shown in the experimental results, this analog synthesis platform is able to generate the required circuits in seconds with low noise. The chip implementation result also verifies the capability of this tool to generate the required designs with fabricable quality.