Locating optimal electrodes placement via microelectrode recording in general anesthetic patients during deep brain stimulation

Wei Yi Chuang*, Kuu-Young Young, Paul C.-P. Chao, Sheng Tzung Tsai, Shin Yuan Chen

*Corresponding author for this work

Research output: Chapter in Book/Report/Conference proceedingConference contributionpeer-review

2 Scopus citations

Abstract

Deep brain stimulation (DBS) is one of promising therapy to treat advanced Parkinson's disease. During DBS operation, general anesthetic induction has been shown an alternative procedure to avoid patient's discomfort under local anesthesia. Meanwhile, microelectrode recording (MER) is a guide of optimal placement in the brain. However, the inhibition of power of neural spiking is assumed by the general anesthesia during the process. Therefore, we use median nerve stimulation (MNS) to enhance them. At the same time, the power of background noise is also enhanced. Then, it makes MER be poor to determine the optimal electrode placement. In this study, we present a methodology including spike detection, fast Fourier transformation and power spectrum analysis for analyzing MER. Through these results, MER data can be successfully utilized for tracking dorsolateral sub thalamic nucleus (STN) to ensure optimal electrode location.

Original languageEnglish
Title of host publicationProceedings - 2012 International Conference on Biomedical Engineering and Biotechnology, iCBEB 2012
Pages1048-1051
Number of pages4
DOIs
StatePublished - 1 Oct 2012
Event2012 International Conference on Biomedical Engineering and Biotechnology, iCBEB 2012 - Macau, China
Duration: 28 May 201230 May 2012

Publication series

NameProceedings - 2012 International Conference on Biomedical Engineering and Biotechnology, iCBEB 2012

Conference

Conference2012 International Conference on Biomedical Engineering and Biotechnology, iCBEB 2012
CountryChina
CityMacau
Period28/05/1230/05/12

Keywords

  • Deep brain stimulation (DBS)
  • dorsolateral subthalamic nucleus (STN)
  • general anesthetic
  • median nerve stimulation (MNS)
  • microelectrode recording (MER)

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