Local stimulation of cultured myocyte cells by femtosecond laser-induced stress wave

Yung En Kuo, Cheng Chi Wu, Yoichiroh Hosokawa*, Yasuyo Maezawa, Kazunori Okano, Hiroshi Masuhara, Fu Jen Kao

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

8 Scopus citations


When an 800 nm femtosecond laser is tightly focused into cell culture medium a stress wave is generated at the laser focal point. Since the stress wave localizes in a few tens of μm, it is possible to locally stimulate single cells in vitro. In this work, several kinds of cultured mammalian cells, HeLa, PC12, P19CL6, and C2C12, were stimulated by the stress wave and the cell growth after the stress loading with the laser irradiation was investigated. In comparison with the control conditions, cell growth after the laser irradiation was enhanced for the cells of C2C12 and P19CL6, which can differentiate into myocytes, and suppressed for PC12 and HeLa cell lines. These results suggest a possibility of cell growth enhancement due to myogenic cells response to the femtosecond laser-induced stress.

Original languageEnglish
Pages (from-to)597-600
Number of pages4
JournalApplied Physics A: Materials Science and Processing
Issue number4
StatePublished - 1 Dec 2010

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