Liquid phase synthesis of chiral quinoxalinones by microwave irradiation

Chieh Li Tung, Chung-Ming Sun*

*Corresponding author for this work

Research output: Contribution to journalArticle

70 Scopus citations

Abstract

Single mode microwave-assisted combinatorial synthesis of biologically interesting quinoxalinones is described. Chiral libraries of quinoxalinone were readily assembled utilizing SNAr reactions, reduction and followed with concomitant cyclization under microwave irradiation. Enantiomeric 1,2,3,4-tetrahydroquinoxalinones were isolated in excellent yield and purity after cleavage.

Original languageEnglish
Pages (from-to)1159-1162
Number of pages4
JournalTetrahedron Letters
Volume45
Issue number6
DOIs
StatePublished - 2 Feb 2004

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