Liquid phase synthesis of arylamines and its application to the benzimidazolone via nucleophilic aryl substitution

Pi Chi Pan, Chung-Ming Sun*

*Corresponding author for this work

Research output: Contribution to journalArticle

15 Scopus citations

Abstract

A method for soluble, inexpensive polymer-supported synthesis of aryl amines and benzimidazolone on the basis of nucleophilic aryl substitution (S(N)Ar) is described. This method involves a direct coupling reaction between resin bound aryl fluoride and amines at ambient temperature. The products are isolated in quantitative yields and excellent purity by simple precipitation and washing. This liquid phase method proves to be a useful tool for constructing combinatorial arylamine and benzimidazolone libraries.

Original languageEnglish
Pages (from-to)1537-1540
Number of pages4
JournalBioorganic and Medicinal Chemistry Letters
Volume9
Issue number11
DOIs
StatePublished - 7 Jun 1999

Keywords

  • Acylation
  • Combinatorial chemistry
  • Liquid-phase synthesis
  • Piperazine

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