Liquid-phase parallel synthesis of ureas

Kuo Ting Huang; Chung-Ming Sun

doi:10.1016/S0960-894X(00)00650-8

Liquid-phase parallel synthesis of ureas

Kuo Ting Huang, Chung-Ming Sun

Department of Applied Chemistry

Research output: Contribution to journal › Article › peer-review

16 Scopus citations

Abstract

An efficient and general liquid-phase method has been developed for the synthesis of a piperazine containing urea library. Reactions of the polymer bound carbamoyl chloride with primary or secondary amines afford ureas at ambient temperature. Desired compounds are liberated from the polymer support under mild conditions in high yields and high purity by simple precipitation and washings.

Original language	English
Pages (from-to)	271-273
Number of pages	3
Journal	Bioorganic and Medicinal Chemistry Letters
Volume	11
Issue number	2
DOIs	https://doi.org/10.1016/S0960-894X(00)00650-8
State	Published - 22 Jan 2001

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title = "Liquid-phase parallel synthesis of ureas",

abstract = "An efficient and general liquid-phase method has been developed for the synthesis of a piperazine containing urea library. Reactions of the polymer bound carbamoyl chloride with primary or secondary amines afford ureas at ambient temperature. Desired compounds are liberated from the polymer support under mild conditions in high yields and high purity by simple precipitation and washings.",

author = "Huang, {Kuo Ting} and Chung-Ming Sun",

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AB - An efficient and general liquid-phase method has been developed for the synthesis of a piperazine containing urea library. Reactions of the polymer bound carbamoyl chloride with primary or secondary amines afford ureas at ambient temperature. Desired compounds are liberated from the polymer support under mild conditions in high yields and high purity by simple precipitation and washings.

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