Liquid-phase parallel synthesis of ureas

Kuo Ting Huang, Chung-Ming Sun

Research output: Contribution to journalArticlepeer-review

16 Scopus citations


An efficient and general liquid-phase method has been developed for the synthesis of a piperazine containing urea library. Reactions of the polymer bound carbamoyl chloride with primary or secondary amines afford ureas at ambient temperature. Desired compounds are liberated from the polymer support under mild conditions in high yields and high purity by simple precipitation and washings.

Original languageEnglish
Pages (from-to)271-273
Number of pages3
JournalBioorganic and Medicinal Chemistry Letters
Issue number2
StatePublished - 22 Jan 2001

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