Liquid-phase parallel synthesis of tetrahydro-β-carbolines

Wen Ben Yeh, Mei Jung Lin, Chung-Ming Sun*

*Corresponding author for this work

Research output: Contribution to journalArticle

22 Scopus citations


Parallel synthesis of β-carbolines on soluble polyethylene glycol (PEG-OH) support is demonstrated. One-pot condensation of polymer-bound tryptophan residues with various aldehydes and ketones has been carried out in the presence of p-TSA as a catalyst to deliver immobilized 1,2,3,4-tetrahydro-β-carbolines. Subsequent disengagement of the appendant from the polymer support afforded the desired products in good yield and acceptable purity.

Original languageEnglish
Pages (from-to)4923-4926
Number of pages4
JournalTetrahedron Letters
Issue number26
StatePublished - 23 Jun 2003

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