Liquid phase parallel synthesis of guanidines

Ko Chieh Ho, Chung-Ming Sun*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

18 Scopus citations


Combinatorial synthesis of N,N'-di(Boc)-Protected guanidines containing piperazine and pyrrolidine scaffolds has been developed. We initiate a preliminary study on the reactivity of several guanylating reagents with soluble polymer-bound diamines in liquid phase. Guanidines are liberated from the polymer support under mild conditions in high yields and high purity by simple precipitation and washings. This combinatorial liquid-phase methodology proves to be a useful tool for constructing guanidine libraries containing diamine scaffolds.

Original languageEnglish
Pages (from-to)1517-1520
Number of pages4
JournalBioorganic and Medicinal Chemistry Letters
Issue number11
StatePublished - 7 Jun 1999

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