Liquid phase combinatorial synthesis of benzylpiperazines

Jing Ying Shey, Chung-Ming Sun*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

10 Scopus citations

Abstract

A novel method for soluble, inexpensive polymer-supported synthesis of piperazine and piperidine libraries on the basis of nucleophilic benzylic substitution and N-acylation is reported. Disubstituted piperazine and piperidine derivatives, that are potential drug candidates, can be isolated in high yields and excellent purity by simple precipitation and washing. This liquid phase method proves to be a useful tool for constructing combinatorial libraries containing diamine moieties.

Original languageEnglish
Pages (from-to)519-522
Number of pages4
JournalBioorganic and Medicinal Chemistry Letters
Volume9
Issue number4
DOIs
StatePublished - 22 Feb 1999

Keywords

  • NMR
  • Polymers
  • Receptors
  • Solid-phase synthesis

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