Liquid-phase combinatorial reaction monitoring by conventional 1H NMR spectroscopy

Jing Ying Shey, Chung-Ming Sun*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

29 Scopus citations


The application of 1H NMR spectroscopy for complete analysis of soluble polymer-supported reactions is described. This conventional analytical technique enables us to determine the extent of liquid-phase reactions without cleavage of the soluble matrix. The polymer matrix permitted us to obtain 1H NMR spectra with a resolution comparable with that of spectra of the molecule in solution.

Original languageEnglish
Pages (from-to)1725-1729
Number of pages5
JournalTetrahedron Letters
Issue number9
StatePublished - 25 Feb 2002


  • Cleavage
  • Combinatorial chemistry
  • Liquid-phase synthesis
  • NMR
  • Substitution

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