Liquid-phase combinatorial reaction monitoring by conventional 1H NMR spectroscopy

Jing Ying Shey, Chung-Ming Sun*

*Corresponding author for this work

Research output: Contribution to journalArticle

29 Scopus citations

Abstract

The application of 1H NMR spectroscopy for complete analysis of soluble polymer-supported reactions is described. This conventional analytical technique enables us to determine the extent of liquid-phase reactions without cleavage of the soluble matrix. The polymer matrix permitted us to obtain 1H NMR spectra with a resolution comparable with that of spectra of the molecule in solution.

Original languageEnglish
Pages (from-to)1725-1729
Number of pages5
JournalTetrahedron Letters
Volume43
Issue number9
DOIs
StatePublished - 25 Feb 2002

Keywords

  • Cleavage
  • Combinatorial chemistry
  • Liquid-phase synthesis
  • NMR
  • Substitution

Fingerprint Dive into the research topics of 'Liquid-phase combinatorial reaction monitoring by conventional <sup>1</sup>H NMR spectroscopy'. Together they form a unique fingerprint.

  • Cite this